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Pericolo infarto per chi usa abitualmente farmaci con ibuprofene e diclofenac 

I famosi medicinali che vengono usati, di solito, per curare qualsiasi tipo di dolore, dal mal di testa al mal di schiena aumenterebbero il rischio di infarto fino al 55% in più. Lo studio condotto da due ricercatrici dell’Università di Nottingham è stato diffuso dal noto quotidiano britannico The Guardian e ha rilevato una percentuale maggiore del rischio di infarto nei soggetti che assumono farmaci contenenti come principio attivo ibuprofene e diclofenac.
Ecco una lista di farmaci che contengono come principi attivi
Ibuprofene
Fenextra, Seractil, Arfen, Brufen, Subitene, Spidifen, Antalfort, Nurofen febbre e dolore bambini, Sinifev, Antalfebal bambini, Ginenorm, Edenil, Moment, Cibalgina, Calmine, Antalgil, Algofen,   Buscofen,  Gineflor, Nurofen, Dolofast, Vicks febbre e dolore, Seractil, Nurofast, Vicks flu-action...
Diclofenac
Algosenac, Deflamat, Dealgic, Diclofan, Fender, Forgernac, Flogofenac, Fenadol, Dicloreum, Voltaren, Voltfast, Artrotec, Pensaid, Diclotears, Diclocular, Dropflam, Dicloftil, Flector, Novapirina, Ribex flu, Solaraze, Itami, Doroxan, Dicloral, Voltadol, Flector, Traulen, Zeroflog, Leviogel, Voltadvance, Dolaut, Eminocs...

Allarme Voltaren, Moment, Buscofen e altri 24 medicinali noti. Pericolo infarto per chi li usa abitualmente. Ecco quali. - A cura di Maria Romano - http://www.retenews24.it
Farmaci e rischio di infarto, sotto accusa Moment e Voltaren - http://www.net1news.org
Farmaci Con Ibuprofene - http://www.medicofacile.it
Farmaci con Diclofenac - http://www.medicofacile.it


Should I stop taking Ibuprofen?
Ibuprofen has been linked to an increased risk of heart attack, stroke and damage to the small intestine. Is it time to take paracetamol instead? 
Luisa Dillner - The Guardian, Sunday 27 April 2014 19.00 BST  http://www.theguardian.com
Ibuprofen tablets. Photograph: Paul Mogfordache/Alamy

It is a mainstay of most medicine cabinets, the painkiller of choice for headaches, back pain and muscle soreness. Ibuprofen is more than 50 years old and one of the most popular non-steroidal anti-inflammatory drugs (NSAID). These drugs reduce inflammation by blocking the enzymes (COX-1 and COX-2) needed to make prostaglandins – chemicals released in response to injury or illness and which cause pain, swelling or fever. Unfortunately, prostaglandins also protect the stomach lining by reducing acid production and increasing mucus, so their blockage can cause stomach bleeding and ulcers, especially in older people.
This has been known for years, but more recently some NSAIDs have been linked to increases in the risk of heart attack (high doses leading to one fatal heart attack for every 1,000 people a year using the drugs), stroke and damage to the small intestine. According to Dr Alessio Fasano, director of the Centre for Coeliac Research at Massachusetts general hospital, they may, in genetically predisposed people, also increase the risk of coeliac disease. By making the small intestine leaky, these drugs allow gluten into the bloodstream and set up an autoimmune response.


Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials
The Lancet, Volume 382, Issue 9894, Pages 769 - 779, 31 August 2013
doi:10.1016/S0140-6736(13)60900-9Cite or Link Using DOI
This article can be found in the following collections: Cardiology & Vascular Medicine (Cardiology & vascular-other); Gastroenterology (Gastroenterology-other) - Published Online: 30 May 2013
http://www.thelancet.com 

The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. 
Major vascular events were increased by about a third by a coxib or diclofenac, chiefly due to an increase in major coronary events. Ibuprofen also significantly increased major coronary events, but not major vascular events. Compared with placebo, of 1000 patients allocated to a coxib or diclofenac for a year, three more had major vascular events, one of which was fatal. Naproxen did not significantly increase major vascular events. Vascular death was increased significantly by coxibs and diclofenac non-significantly by ibuprofen, but not by naproxen. The proportional effects on major vascular events were independent of baseline characteristics, including vascular risk. Heart failure risk was roughly doubled by all NSAIDs. All NSAID regimens increased upper gastrointestinal complications.
The vascular risks of high-dose diclofenac, and possibly ibuprofen, are comparable to coxibs, whereas high-dose naproxen is associated with less vascular risk than other NSAIDs. Although NSAIDs increase vascular and gastrointestinal risks, the size of these risks can be predicted, which could help guide clinical decision making.
Funding: UK Medical Research Council and British Heart Foundation.


Research Shows Link Between NSAID Use and Gut Disease
Popping an ibuprofen after a workout or for a headache seems safe enough, right? Recent research shows the OTC drug could be contributing to leaky gut syndrome and celiac disease.
Leaky Gut  04.21.14 - http://www.thedailybeast.com

Anyone who suffers from gluten sensitivity, intolerance, or celiac disease knows how troublesome the problem is. Unlike some immediately life-threatening allergies, such as peanut or seafood, gluten allergies don’t send their sufferers into anaphylactic shock. Rather, those who suffer from gluten sensitivities and celiac disease have a myriad of potential problems to deal with, including gastro-intestinal problems, hives, pain, arthritis, and even cloudy thinking and depression.
Recently, some gluten-free champions have revisited studies from the past 20 years that show NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen might just play a contributing role by increasing the likelihood of leaky gut syndrome. According to one NIH study, “All the conventional NSAIDs studied were equally associated with small intestinal inflammation apart from aspirin…” and “intestinal permeability changes were significantly more pronounced” with some of the tests.
Dr. Alessio Fasano, the director of the Center for Celiac Research at Massachusetts General Hospital, agrees. “There are many factors that seem to play a role. The use and abuse of antibiotics—anything that affects the macrobiotics of the gut.”
Fasano says that those born by C-section seem to have higher likelihood of developing gluten sensitivities, and those who were breast fed seem to be protected from it. “But this is all ‘a work in progress’… [that] we are trying to confirm or refute.”
“From what we understand, [with NSAIDs] one of the side effects is that they can affect the permeability of the gut,” says Fasano. “Now, you have increased passage of gluten, and if you are genetically predisposed, you can develop celiac or gluten-intolerance.”
Fasano says patients need to ask themselves, “What are the pros and cons of taking this drug?” For someone who has chronic inflammation who cannot take steroids all the time, it might be beneficial to take NSAIDs to deal with the problem, but for someone who suffers regularly from a runny nose, “it would be better if you don’t take it.”